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Home / Recent Patents on CNS Drug Discovery (Discontinued), Volume 5, Number 3

Pharmacological Therapy of Parkinson's Disease: Current Options and New Avenues

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Parkinson's disease is a neurodegenerative pathology which affects the dopaminergic neurons in the mesencephalon, leading to a progressive and relentless motor disability and to non-motor symptoms of different severity. The aim of this review is to summarize the features of drugs currently used in the pharmacotherapy of Parkinson's disease, with a look at their beneficial effects and limitations. Drugs acting on dopamine transmission, as L-DOPA, direct dopaminergic agonists, inhibitors for either the MAO or COMT enzymes and drugs acting on neurotransmitters other than dopamine (e.g. acetylcholine, glutamate) will be covered. Investigational drugs currently under examination for their therapeutic potential in Parkinson's disease and recent patents which may be relevant to the field will be also discussed.





Keywords: Adenosine A2A Receptor; Alzheimer's disease; Amantadine; Apomorphine; Autonomic Dysfunction; Biosynthesis of dopamine; Bromocriptine; COMT inhibitors; Catechol-O-Methyl Transferases; Cholinergic Transmission; Cognitive Impairment; Hallucinations; L-DOPA; Lisuride; MAO inhibitors; Memantine; Monoamine Oxidases; Mood Disorders; Neurobehavioral Problems; Parkinson's Disease; Pergolide; Pramipexole; Psychosis; Ropinirole; SNc DAergic neurons; Selegiline; acetylcholine; acetylcholine (Ach)DA replacement therapy (DRT); akinesia, bradykinesia; amantadine; anticholinergics; dopamine direct agonists; dopamine transmission; dopaminergic neurons; entopeduncular nucleus (EPN); globus pallidus (GPe); glutamate; motor impairment; neurodegenerative pathology; neurotransmitters; norepinephrine (NE); olfactory dysfunction; pardoprunox; serotonin; substantia nigra reticulata (SNr); subthalamic nucleus (STN)

Document Type: Research Article

Publication date: 01 November 2010

More about this publication?
  • Recent Patents on CNS Drug Discovery publishes review articles on recent patents in the field of CNS drug discovery e.g. novel bioactive compounds, analogs & targets. A selection of important and recent patents on CNS drug discovery is also included in the journal. The journal is essential reading for all researchers involved in CNS drug design and discovery.

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