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Antimicrobial Properties of Organosulfur Anti-Infectives: A Review of Patent Literature 1999-2005

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The number of organosulfur compounds being patented has been growing. A wide variety of these organosulfur compounds, whether naturally occurring or synthetic, exhibit antibacterial properties. Mechanistically, organosulfur groups can act as metal chelators, powerful nucleophiles or electrophiles depending on the local environment in which a given reaction occurs. In this review of the patent literature from 1999-2005, the reliance of these compounds on the reaction of the sulfur moiety with its biological target(s) will be discussed with regards to activity, specificity, and antimicrobial spectrum.

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Keywords: Allicin; Organosulfur compounds; antimicrobials; metallo-β lactamases; sulfides; thioethers; thiols; thiosulfinates

Document Type: Research Article

Affiliations: Department of Chemistry, American University, 4400 Massachusetts Avenue, NW, Washington, DC, 20016-8014, USA.

Publication date: June 1, 2006

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  • Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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