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Recent Progress in Pharmacological Research of Antioxidants in Pathological Conditions: Cardiovascular Health

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Antioxidants are essential, and are involved in several important biological processes such as immunity, protection against tissue damage, reproduction, growth and development. Antioxidants preserve adequate function of cells against homeostatic disturbances such as those caused by septic shock, aging and, in general, processes involving oxidative stress. Each year, many scientific articles are published describing the pharmacological and biological properties of antioxidants. This review article compiles recent findings on these properties, focusing mainly on the anti-inflammatory properties of antioxidants in different pathological areas, such as cardiovascular damage and sepsis. In relation to this process, this review focuses on the involvement of reactive oxygen and nitrogen species. Finally, the protective role of antioxidants against homeostatic disturbances such as those caused by endotoxin toxicity and cardiovascular damage, their potential clinical use, and the effects on the redox state of immune cells are discussed.





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Keywords: Antioxidant; N-acetylcysteine; NF-kB; cardiovascular dysfunction; endotoxin; flavonoids; immune system; ischemia; mitochondria; nitric oxide; patent; peroxynitrite; reactive oxygen species; septic shock; vitamin

Document Type: Research Article

Affiliations: (VM Victor) at Centro Nacional de Investigaciones Cardiovasculares (CNIC), Universidad de Valencia, Departamento de Farmacologia, Facultad de Medicina, Avda. Blasco Ibanez 15, 46010 Valencia, Spain;

Publication date: January 1, 2006

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  • Recent Patents on Anti-Infective Drug Discovery publishes review articles on recent patents in the field of anti-infective drug discovery e.g. on novel bioactive compounds, analogs & targets. A selection of important and recent patents on anti-infective drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-infective drug design and discovery.
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