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Peptoid Analogues of Anoplin Show Antibacterial Activity

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We have synthesised nine analogues of the antibacterial peptide anoplin with a peptoid residue at position 5 (HGLLKXIKTLL- NH2). The most active compounds showed MIC-values of 12.5 and 25 μM against E.coli and S.aureus. These MIC-values are comparable with anoplin which showed 23 μM and 11 μM against E.coli and S.aureus. However, the selectivity was reversed. Our results indicate that peptoid analogues of anoplin are promising lead structures for developing new antibacterial agents.

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Keywords: Anoplin; antibacterial agents; peptoid; solid-phase synthesis

Document Type: Research Article

Publication date: September 1, 2009

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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