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Design and Synthesis of Metal-Free Artificial Ribonucleases

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The present review is aimed at giving a general overview of our results in the field of designing and synthesizing simple peptide-like molecules that mimic structural and functional aspects of natural ribonucleases, as well as designing oligonucleotide-based artificial ribonucleases.

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Keywords: Artificial ribonucleases; RNases mimics; oligonucleotide conjugates

Document Type: Research Article

Affiliations: Institute of Chemical Biology and Fundamental Medicine, 8 Lavrentiev prosp., Novosibirsk, 630090,Russia.

Publication date: February 1, 2007

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  • Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
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