Isolation and Structural Characterization of a Peptide from the Venom of Scorpion with Toxicity Towards Invertebrates and Vertebrates
Using a methodology based on HPLC fractionation, mass spectrometry analysis, and microinjection guide-bioassays, a peptide with toxicity to both insects and mammals was isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus, and named LqhIV (after LqhII and LqhIII[1]). The primary sequence, circular dichroism spectrum and three-dimensional structure simulation of LqhIV indicate that it contains similar structure to that of the group of alpha scorpion toxins.
Keywords: Androctonus australis; Hebraeus; Leiurus quinquestriatus hebraeus; Leiurus quinquestriatus quinquestriatus; Quinquestriatus
Document Type: Review Article
Affiliations: Suntory Institute for Bioorganic Research, Mishima-Gun, Shimamoto-Cho, Wakayamadai 1-1-1, Osaka 618-8503, Japan.
Publication date: 01 October 2001
- Protein & Peptide Letters publishes short papers in all important aspects of protein and peptide research, including structural studies, recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, drug design etc. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallisation, and preliminary structure determinations of biologically important proteins are acceptable. Purely theoretical papers are also acceptable provided they provide new insight into the principles of protein/peptide structure and function.
- Editorial Board
- Information for Authors
- Subscribe to this Title
- Ingenta Connect is not responsible for the content or availability of external websites
Receive new issue alert- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content