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Spirooxindoles as Potential Pharmacophores

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Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.

Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.

This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.

Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.
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Keywords: Biological importance; chemistry; heterocycles; pharmacophores; spirooxindoles; synthesis

Document Type: Research Article

Publication date: November 1, 2017

More about this publication?
  • The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

    The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

    Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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