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Potential Health Hazards for Cumulative Exposures to Phthalates and Ionizing Radiation in High-Risk Pediatric Population

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Objective: Ionizing radiation has been shown to impact and possibly alter the normal structure and function of living cells and is dangerous for human health, especially when exposure occurs early in life. Additionally, radiation can interact with other dangerous substances in the same environment, such as phthalates. Phthalates are a group of multifunctional molecules used in a wide range of consumer products, as plasticizers to impart flexibility, durability and strength to otherwise rigid polyvinyl chloride. They are not chemically bound to polyvinyl chloride, and thus migrate into the environment with time and use, becoming ubiquitous environmental contaminants.

Conclusion: There is a growing concern about the effect that exposure to ionizing radiation and phthalates can have on human health, and the biological effects of this cumulative exposure are particularly troubling in infants due to children's inherent sensitivity. Pediatric patients are exposed to numerous plastic medical devices and often require multiple radiologic examinations for their complex medical conditions. Risk assessment requires a more complete evaluation of the effects of simultaneous and cumulative exposure, especially in high-risk patients.
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Keywords: DEHP; Ionizing radiation; human health; neonates; phthalates; polyvinyl chloride

Document Type: Research Article

Publication date: November 1, 2017

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  • The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

    The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

    Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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