Medicinal Chemistry and Biological Properties of Non-Imidazole Histamine H3 Antagonists
The H3 receptor is prominently expressed in neuronal tissues, and H3 antagonists have been proposed as drugs with benefits in disorders of cognition, attention, pain, allergic rhinitis, and obesity. The structure-activity relationships (SAR) of various classes of non-imidazole H3 antagonists are reviewed, along with highlights of functional efficacy in tissue-based and animal disease models.
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Document Type: Review Article
Affiliations: Department of Neuroscience Research, GPRD R4MN, Abbott Labs, AP9a 216, Abbott Park, IL 60073-6123, USA.
Publication date: November 1, 2004
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