Medicinal Chemical and Pharmacological Aspects of Imidazole-Containing Histamine H3 Receptor Antagonists
The first antagonists known for the histamine H3 receptor were mono-substituted imidazolecontaining compounds like thioperamide. Meanwhile numerous novel leads have been developed possessing improved affinities, selectivities, specificities, and pharmacokinetic properties. Scope and limitations of this promising class are discussed concerning their structure-activity relationships as well as pharmacological and potential therapeutic aspects.
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Document Type: Review Article
Affiliations: Johann Wolfgang Goethe-Universitat, Institut fur Pharmazeutische Chemie, Biozentrum, Marie- Curie-Strasse 9, 60439 Frankfurt am Main, Germany.
Publication date: November 1, 2004
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