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Histamine H3 Receptor Agonists

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The SAR of H3 ligands has been difficult to evaluate because of species differences, multiple isoforms and constitutive activity, among other complicating factors. A review is given of the sometimesconflicting affinity, activity and efficacy data of H3 agonists that has been described in literature to date.
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Keywords: activity; affinity; agonist; efficacy; gpcr; h3; histamine; isoform

Document Type: Review Article

Affiliations: De Novo Pharmaceuticals,Compass House, Vision Park Histon, Cambridge CB4 9ZR, UK.

Publication date: November 1, 2004

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  • The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines.

    The scope of Mini-Reviews in Medicinal Chemistry will cover all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies.

    Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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