An Expedient Synthesis and Screening for Antiacetylcholinesterase Activity of Piperidine Embedded Novel Pentacyclic Cage Compounds
The aim of this study was to synthesize and evaluate diazapentacyclic analogs for their acetylcholinesterase (AChE) inhibitory activity. The pentacyclic analogs were synthesized by one-pot three-component domino reactions in a microwave synthesizer. Most of the compounds exhibited moderate
to good AChE inhibitory activity, compound 5i showed potent inhibitory activity with IC50 1.12±0.01 μM and this may provide a new lead for developing potential inhibitors for Alzheimer's disease.
Keywords: 1; 3-Dipolar cycloaddition; AChE inhibitor; Alzheimer's disease; azomethine ylide; diazapentacycles and microwave irradiation
Document Type: Research Article
Publication date: 01 March 2014
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