Skip to main content
padlock icon - secure page this page is secure

Synthesis, Cytotoxic Evaluation and In Silico Pharmacokinetic Prediction of Some Benzo[a]Phenazine-5-sulfonic acid Derivatives

Buy Article:

$68.00 + tax (Refund Policy)

Cancer is one of the life threatening diseases and the development of novel anticancer molecules is limited by many reasons. In the present investigation, some novel benzo[a]phenazine-5-sulfonic acid derivatives as DNA intercalator was designed with optimized pharmacokinetic features for cancer treatment. The compounds with desired pharmcokinetic profile were synthesized and structurally characterized. Cytotoxic activity study against HL-60 tumor cell lines shows that 10-dimethyl carboxamido derivative of benzo[a]phenazine-5-sulfonic acid is found to be the most active in the series with cytotoxic activity (IC50 = 19 μM) comparable to cisplatin (IC50 = 7 μM). The study concluded that the novel benzo[a]phenazine-5-sulfonic acid derivatives were found to have enhanced DNA binding affinity and exhibited significant activity in vitro against HL-60 cell lines. This work will also guide for further development of effective DNA intercalators for cancer treatment.





No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Benzo[a]phenazine-5-sulfonic acid; cytotoxic activity; human leukemia; in silico pharmacokinetic

Document Type: Research Article

Publication date: November 1, 2009

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more