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Germatranyl Substituted Organotin (IV) Carboxylates: Synthesis Spectroscopic Characterization and Biological Activities

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Eight new organotin (IV) derivatives of general formula [N(CH2CH2O)3GeCH(R1)CH2COO]4-nSnR2 n, where n = 2, R2 = C2H5 (1-5); R1 = CH3 (1); C6H5 (2); p-CH3C6H4 (3); p-FC6H4(4); p-CH3OC6H4 (5) and n = 3, R2 = CH2C6H5 (6- 8), R1 = CH3 (6); C6H5 (7); p-CH3C6H4 (8) have been synthesized by the reaction of di- or tri-organotin chloride with the corresponding germatranyl (substituted) propionic acid in the appropriate mole ratios using triethylamine as a base. The synthesized compounds were characterized by various spectroscopic techniques such as IR, multi-nuclear (1H, 13C, 119Sn) NMR, 119mSn Mossbauer, along with elemental analyses. They were also screened for in vitro anti-leishmanial activity against promastigotes of leishmania donovani and found some encouraging results.

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Keywords: Germatranes; antileishmanial activity; diethyltin; spectroscopy; tribenzyltin

Document Type: Research Article

Publication date: November 1, 2009

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