Lipid-Lowering Effects of Polymers Derived from Halophenyl Pyrroles
2,4-Disubstituted pyrroles were polycondensed and tested for lipid-lowering effects in mice. Fluoro-substituted pyrrole monomers and polymers lowered total serum cholesterol by 30-35% and LDL-cholesterol by 47-64%. The lipidlowering effects were similar for polymers and
their monomers, however, the polymers produced these effects at dosage concentrations 1/8th that of the monomers.
Keywords: Carboxylic acids; Cardiovascular disease; HDL; Halophenyl Pyrroles; LDL; Lipid; cholesterol; colistipol; ezetimibe; lipids; polymers; pyrroles; regioselective synthesis; total serum cholesterol; triglycerides
Document Type: Research Article
Publication date: July 1, 2011
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