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Lipid-Lowering Effects of Polymers Derived from Halophenyl Pyrroles

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2,4-Disubstituted pyrroles were polycondensed and tested for lipid-lowering effects in mice. Fluoro-substituted pyrrole monomers and polymers lowered total serum cholesterol by 30-35% and LDL-cholesterol by 47-64%. The lipidlowering effects were similar for polymers and their monomers, however, the polymers produced these effects at dosage concentrations 1/8th that of the monomers.

Keywords: Carboxylic acids; Cardiovascular disease; HDL; Halophenyl Pyrroles; LDL; Lipid; cholesterol; colistipol; ezetimibe; lipids; polymers; pyrroles; regioselective synthesis; total serum cholesterol; triglycerides

Document Type: Research Article

Publication date: July 1, 2011

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  • Letters in Drug Design & Discovery publishes original letters on all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis will be on publishing quality papers very rapidly. Letters will be processed rapidly by taking full advantage of Internet technology for both the submission and review of manuscripts. The journal is essential reading to all pharmaceutical scientists involved in research in drug design and discovery.
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