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Umbilical IgE and Advanced Glycation Products in Association with Allergies in Childhood

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Background: Little is known regarding the possibility of predicting allergy in genetically susceptible individuals.

Objective: We endeavored to measure the levels of IgE, IgA and advanced glycation end products (AGEs) in the umbilical blood of newborns of allergic parents.

Method: We collected two groups of newborns, the first group of 20 subjects with nonatopic parents, and the second with 20 subjects with a history of allergy in one or both parents.

Results: Neonates born to parents with allergies had increased levels of AGEs in their umbilical cord blood.

Conclusion: This causes increased oxidative stress and an increased probability of allergy and asthma in a child ´s future. We therefore propose that such children should be followed with the aim of lowering AGEs and IgE throughout life.
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Keywords: Advanced glycation end products; allergy; immunoglobulin E; neonates; oxidative stress; umbilical blood

Document Type: Research Article

Publication date: June 1, 2016

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  • Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in the medicinal chemistry and rational drug design for the discovery of new Immunology, Endocrine & Metabolic Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Immunology, Endocrine & Metabolic medicinal chemistry.

    Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in Immunology, Endocrine & Metabolic drug discovery.
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