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Umbilical IgE and Advanced Glycation Products in Association with Allergies in Childhood
Background: Little is known regarding the possibility of predicting allergy in genetically susceptible individuals.
Objective: We endeavored to measure the levels of IgE, IgA and advanced glycation end products (AGEs) in the umbilical blood of newborns of allergic parents.
Method: We collected two groups of newborns, the first group of 20 subjects with nonatopic parents, and the second with 20 subjects with a history of allergy in one or both parents.
Results: Neonates born to parents with allergies had increased levels of AGEs in their umbilical cord blood.
Conclusion: This causes increased oxidative stress and an increased probability of allergy and asthma in a child ´s future. We therefore propose that such children should be followed with the aim of lowering AGEs and IgE throughout life.
Objective: We endeavored to measure the levels of IgE, IgA and advanced glycation end products (AGEs) in the umbilical blood of newborns of allergic parents.
Method: We collected two groups of newborns, the first group of 20 subjects with nonatopic parents, and the second with 20 subjects with a history of allergy in one or both parents.
Results: Neonates born to parents with allergies had increased levels of AGEs in their umbilical cord blood.
Conclusion: This causes increased oxidative stress and an increased probability of allergy and asthma in a child ´s future. We therefore propose that such children should be followed with the aim of lowering AGEs and IgE throughout life.
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Keywords: Advanced glycation end products; allergy; immunoglobulin E; neonates; oxidative stress; umbilical blood
Document Type: Research Article
Publication date: June 1, 2016
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