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The Potentials of Selected Therapeutic Targets for Inflammation: A Snapshot

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Inflammation is a complex integrated host response to infection and injury. Inflammatory cells respond to foreign substances and inflammatory stimulus by producing various chemical bioactive mediators such as prostanoids, cytokines and chemokines. These mediators have complex, pleiotropic effects and interact with many cell types and cellular pathways to amplify the inflammatory response. Dysregulation of these processes can lead to acute and chronic inflammatory diseases necessitating pharmacological intervention to attenuate cellular inflammation pathways. This review focuses on new targets and alternative approaches to the development of novel therapeutics based on the endogenous chemicals mediators and the regulation of the associated cellular pathways that modulate inflammation leading its resolution and patents relevant to these targets.
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Keywords: ATP (adenosine triphosphate); Adiponectin; NF-κB; PAR (protease-activated receptor; PPAR-γ; ROS (reactive oxygen species); adenosine triphosphate; chemokine; cyclooxygenase-2; heme oxygenase (HO)-1; inflammation; protectin; resolvin

Document Type: Research Article

Publication date: May 1, 2012

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  • Recent Patents on Inflammation & Allergy Drug Discovery publishes review articles by experts on recent patents in the field of inflammation and allergy drug discovery e.g. on novel bioactive compounds, analogs and targets. A selection of important and recent patents in the field is also included in the journal. The journal is essential reading for all researchers involved in inflammation and allergy drug design and discovery.
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