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Combinatorial Approaches in Anticancer Drug Discovery: Recent Advances in Design and Synthesis

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Combinatorial technology for the generation of molecular diversity has evolved as an integrated component in accelerated drug discovery process. During the emerging days of combinatorial chemistry, solidphase organic synthesis has been the leading strategy for the production of large libraries for lead discovery. As combinatorial techniques for the library synthesis has evolved, solution-phase synthesis of smaller, targeted libraries is gaining attention. Numerous syntheses of biologically active chemical libraries of small molecules have been reported during the past decade. This review will focus only on the recent literature of chemical libraries targeted towards anticancer properties. The synthesis, chemistry and biological activity of these libraries as anticancer agents are summarized.
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Keywords: Anticancer; combinatorial; nephropathy

Document Type: Review Article

Affiliations: Argonaut Technologies, 1101 Chess Drive, Foster City, CA 94404, USA.

Publication date: January 1, 2004

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