Mechanism by which Regulatory Rheumatoid Factor Prevents Experimental Autoimmune Encephalomyelitis
Objective: The aim of this study is to test the hypothesis that regRF prevents autoimmunity by limiting the expansion of lymphocytes.
Methods: To test this hypothesis, we used a model of experimental autoimmune encephalitis.
Results: We found that in the lymph nodes that drain the injection site in rats producing regRF in response to immunization with myelin basic protein (MBP) the proportion of CD4+lymphocytes was lower than in rats in which MBP-immunization did not induce higher regRF levels. RegRF-containing plasma obtained from MBP-immunized rats induces complement-dependent killing of MBP-activated lymphocytes. Activated MBP-specific lymphocytes are not sensitive to the regRF-containing plasma of intact rats.
Conclusion: The regRF produced during the immune response is a specific control factor for the expansion of antigen-activated CD4+lymphocytes.
Keywords: CD4+CD95+ lymphocytes; Experimental autoimmune encephalomyelitis; activated CD4+ lymphocytes; complement-dependent lysis; controlled contraction of lymphocyte expansion; regulatory rheumatoid factor
Document Type: Research Article
Publication date: November 1, 2018
- This journal is devoted to timely reviews of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Topics related to the neuroendocrine-immune axis are given special emphasis in view of the growing interest in stress-related, inflammatory, autoimmune, and degenerative disorders.
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