Skip to main content
padlock icon - secure page this page is secure

The Leptin System: A Potential Target for Sepsis Induced Immune Suppression

Buy Article:

$68.00 + tax (Refund Policy)

Sepsis, which is defined as a systemic inflammatory response syndrome that occurs during infection, is associated with several clinical conditions and high mortality rates. As sepsis progresses immune paralysis can become severe, leaving an already vulnerable patient ill equipped to eradicate primary or secondary infections. At present the predominant treatments for sepsis have not demonstrated convincing efficacy of decreased mortality. During sepsis, it has been observed that leptin levels initially increase but subsequently decline. A body of evidence has demonstrated that central or systemic leptin can beneficially regulate immune function. In this report expression of leptin and its receptor, signaling, and function on leukocytes will be reviewed. Furthermore, the effects mediated by central and systemic leptin during sepsis will be reviewed. Altogether, the ability of leptin to beneficially enhance inflammation and the host response during sepsis supports its use as a therapeutic agent, particularly during the latter phases of the syndrome.

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: 3-phosphatidylinositol; 5-adenosine monophosphate-activated protein kinase; ANS; G-CSF receptor; HPA; Leptin; Protein tyrosine phosphatase 1B; SNS; T cell; Tyrosine Phosphorylation; anti-microbial; autonomic nervous system; choroid plexus; cytokine receptor homology; cytokine signaling 3; extracellular signaling pathway; hematopoiesis; hypothalamo-pituitary adrenocortical; hypothalamus; insulin receptor substrate; leptin protein receptor; macrophage; neutrophil; peripheral blood mononuclear cells; phosphatase 1B; pro-opiomelanocortin; rapamycin; sympathetic nervous system; thermogenesis; tumor necrosis factor alpha (TNF); ventromedial

Document Type: Research Article

Publication date: December 1, 2010

More about this publication?
  • This journal is devoted to timely reviews of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Topics related to the neuroendocrine-immune axis are given special emphasis in view of the growing interest in stress-related, inflammatory, autoimmune, and degenerative disorders.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more