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Fibrosis in the Anterior Segments of the Eye

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The anterior segment of the eye ball, i. e., cornea and conjunctiva, serves as the barrier to the external stimuli. Cornea is transparent and is a “window” of the light sense, while conjunctiva covers the sclera, the main part of the eyeshell. Fibrosis/scarring in cornea potentially impairs vision by the reduction of its transparency and the alteration of the regular curvature. Fibrotic reaction in conjunctiva is also of clinical importance because inflammatory fibrosis in this tissue affects the physiology of the cornea and also a problem of post-eye surgery. In this review, we discuss the topic that is quite critical in vision. Although, various growth factors have been considered to be involved in, focus was put on the roles of transforming growth factor β (TGFβ).

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Keywords: CJun-N-terminal kinase; CTGF; Conjunctiva; Connective tissue growth factor; Cornea; Fibrosis; GAGs; Glaucoma; MAPK; Myofibroblasts; Smad7; Stevens-Johnsons syndrome; TGF; TNF/JNK signal pathways; bleb tissue; epithelium homeostasis; glycosaminoglycans; interferon-gamma andgene therapy; interleukin-7; mesenchymal cells; mitogen-activated kinase; ocular surfacescarring diseases; retina; subconjunctivalfibroblasts; surgical fistula; vernal conjunctivitis

Document Type: Research Article

Publication date: December 1, 2010

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  • This journal is devoted to timely reviews of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Topics related to the neuroendocrine-immune axis are given special emphasis in view of the growing interest in stress-related, inflammatory, autoimmune, and degenerative disorders.
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