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Chronomodulated Delivery System: a Tailored Cap to Fit Different Heads

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“Blind race ends in a pit”. A similar scenario is observed with the use of conventional dosage forms for different pathological conditions. Of late various disease states had regularly been reported to bear direct concurrence to the body’s secretions that bear a constant rotationary cycle. Moreover the pharmacokinetic as well as pharmacodynamic responsiveness of various drugs had been reported to bear constant swings with the changing hours of the day. Thus, usage of the conventional zero order dosage form for every disease state or every active moiety developed, will only leave the researchers as well as the consumers in doldrums. Chronomodulated dosage forms are a silver lining in these overshadowed clouds. They are the dosage forms that spearhead the innovative researches because of their pre-programmed and pre-regulated pulsed release of the drug, at desired sites. Drug release pattern from these dosage forms considerably mimics the circadian timing of the body’s secretion which are held responsible for the symptoms of the pathological irregularities arising in one’s body. Thus, in a way these dosage forms are a shield against the inducers of the disease symptoms. Current review enlists the pathological states for which the chronomodulated delivery systems can prove to be a miraculous cure. This review emphasizes to summarize the patents granted as well as the novel researches undertaken by various researchers to upgrade the previously existing dosage form scenario. Moreover, this work is an attempt to summarize the various proprietary techniques and marketed formulations, thus trying to help the researchers to fabricate a better and novel dosage form from previously existing ones.
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Keywords: "CHRONOMODULATED DELIVERY SYSTEMS"; Capsule Type Delivery System; Chronomodulated; Circadian Rhythmicity; Hydrogel Based System; Multi Particulate System; Polymer coated pellets; Tablets Based System; circadian; pharmacodynamic

Document Type: Research Article

Affiliations: Meerut Institute of Engineering and Technology, NH-58, Baghpat Bypass, Meerut- 250005, Uttar Pradesh, India.s.

Publication date: August 1, 2012

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  • Recent Patents on Drug Delivery and Formulation publishes review articles by experts on recent patents on drug delivery and formulation. A selection of important and recent patents on drug delivery and formulation is also included in the journal. The journal is essential reading for all researchers involved in the fields of drug delivery and formulation.
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