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Recent Advances in Chitosan Films for Controlled Release of Drugs

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Chitosan is a versatile carrier for biologically active agent from a small molecule such as an antibiotic to macromolecules such as proteins and nucleic acids. In addition, drug delivery devices based on chitosan can be available in a variety of morphologies including films, fibers, nanoparticles and microspheres. Otherwise the inherent advantages of this polymer such as biocompatibility, tissue adhesions and hydrophilic nature, chitosan can be modified to accomplish a specific purpose, for example improves release kinetics. In this review, recent patents of chitosan-based film systems for drug delivery are presented and discussed. This review include matrix type systems, membrane coated systems and film forming solution. For each one of these systems, several examples of manufacture processes, bioactive agents to be delivered and specifics applications are considered. This work highlights the use of chitosan in the film technology for drug delivery, presenting examples of chitosan used in an unmodified state and examples of modifications of the polymer backbone.
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Keywords: "Unmodified CHT Systems"; Chitosan film; Excipients; Film Forming Solutions; Membrane Coated Systems; chitosan modification; drug delivery; film forming solution; matrix systems; membrane coated systems

Document Type: Research Article

Affiliations: 1: Laboratorio de Quimica Fina, Instituto de Desarrollo Tecnologico para la Industria Quimica (INTEC), Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Cientificas y Tecnicas (UNL-CONICET), CCT CONICET-SANTA FE, Ruta Nacional 168, Paraje El Pozo, 3000, Santa Fe, Argentina. 2: Laboratorio de Quimica Fina, Instituto de Desarrollo Tecnologico para la Industria Quimica (INTEC), Universidad Nacional del Litoral and Consejo Nacional de Investigaciones Cientificas y Tecnicas (UNL-CONICET), CCT CONICET-SANTA FE, Ruta Nacional 168, Paraje El Pozo, 3000, Santa Fe, Argentina.

Publication date: August 1, 2012

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  • Recent Patents on Drug Delivery and Formulation publishes review articles by experts on recent patents on drug delivery and formulation. A selection of important and recent patents on drug delivery and formulation is also included in the journal. The journal is essential reading for all researchers involved in the fields of drug delivery and formulation.
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