Systemic Delivery of siRNA: Challenging but Promising
Small interfering RNA (siRNA) is a small, double-stranded RNA molecule that can suppress expression of specific genes. It will be a promising therapeutic agent for the treatment of viral and genetic diseases, such as HIV infection and cancer. However, it is extremely challenging to systemically deliver siRNA to the intended sites of action due to a variety of extracellular and intracellular barriers. Over the past decade, many novel patents have been developed to improve delivery efficiency and therapeutic efficacy of siRNA. The features of the carriers and technologies for systemic delivery of siRNA in these patents are summarized, and their clinical applications are discussed in this review.
No Supplementary Data
No Article Media
Document Type: Research Article
Publication date: April 1, 2012
More about this publication?
- Recent Patents on Drug Delivery and Formulation publishes review articles by experts on recent patents on drug delivery and formulation. A selection of important and recent patents on drug delivery and formulation is also included in the journal. The journal is essential reading for all researchers involved in the fields of drug delivery and formulation.
- Editorial Board
- Information for Authors
- Subscribe to this Title
- Ingenta Connect is not responsible for the content or availability of external websites