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Research Progress of Axl Inhibitors

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Axl, a Receptor Tyrosine Kinase (RTK) belonging to the TAM (Axl, Mer, Tyro3) family, participates in many signal transduction cascades after mostly being stimulated by Growth arrestspecific 6(Gas6). Axl is widely expressed in many organs, such as macrophages, endothelial cells, heart, liver and skeletal muscle. Over-expression and activation of Axl are associated with promoting chemotherapy resistance, cell proliferation, invasion and metastasis in many human cancers, such as breast, lung, and pancreatic cancers. Therefore, the research and development of Axl inhibitors is of great significance to strengthen the means of cancer treatment, especially to solve the problem of drug resistance. Axl inhibitors have attracted more and more researchers' attention in recent years. This review discusses the research progress of Axl inhibitors in recent years.
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Keywords: Axl; Cancer; Drug resistance; Gilteritinib; Natural products; Targeted therapy

Document Type: Review Article

Publication date: June 1, 2019

This article was made available online on July 1, 2019 as a Fast Track article with title: "Research Progress of Axl Inhibitors".

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