Skip to main content
padlock icon - secure page this page is secure

Coumarins as Promising Scaffold for the Treatment of Age-related Diseases – An Overview of the Last Five Years

Buy Article:

$68.00 + tax (Refund Policy)

Degenerative diseases are becoming more common with increasing life expectancy of the human population. The 20th century faced a progressive demographic change in the industrialized world, followed by identical trends in population aging in Asia, Africa, and Middle and South America. A significant increase in chronic age-dependent disorders will soon cause important challenges for several countries. Age-related pathologies are commonly seen in elderly patients. More than 40% of adults over 60 years old present a combination of risk factors, described as metabolic syndrome, which significantly increases the tendency for developing degenerative diseases, and some types of cancers. Among these, Parkinson's, Alzheimer's and cardiovascular diseases are on the top of the list. The discovery of effective cardio- and neuroprotective alternative therapeutics that decrease or block disease's progression at early stages, is the main goal of research groups working in the field. A wide range of different substituted coumarins, and the pharmacological properties they may display, are trend topics because of their synthetic accessibility, as well as their abundance in plants and other naturally-occurring products. These heterocyclic compounds play an important role in a variety of areas, but stand out in the field of Medicinal Chemistry. This review provides an overview of the last five years about the potential of coumarins as modulators of several physiological mechanisms involved in age-related pathologies.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Age-related diseases; Alzheimer's metabolic syndrome; Cardiovascular diseases; Coumarins; Neurodegenerative diseases

Document Type: Review Article

Publication date: November 1, 2017

This article was made available online on December 20, 2017 as a Fast Track article with title: "Coumarins as Promising Scaffold for the Treatment of Age-related Diseases – An Overview of the Last Five Years".

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more