Skip to main content
padlock icon - secure page this page is secure

Hybrid Compounds as Anti-infective Agents

Buy Article:

$68.00 + tax (Refund Policy)

Hybrid drugs are multi-target chimeric chemicals combining two or more drugs or pharmacophores covalently linked in a single molecule. In the field of anti-infective agents, they have been proposed as a possible solution to drug resistance issues, presumably having a broader spectrum of activity and less probability of eliciting high level resistance linked to single gene product. Although less frequently explored, they could also be useful in the treatment of frequently occurring co-infections. Here, we overview recent advances in the field of hybrid antimicrobials. Furthermore, we discuss some cutting-edge approaches to face the development of designed multi-target agents in the era of omics and big data, namely analysis of gene signatures and multitask QSAR models.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Anti-infective; Antibiotic; Antifungal; Antimicrobial; Antimicrobial resistance; Antiviral; Chimeric molecule; Hybrid drug; Hybrid molecule; Multi-target agents; Multi-target drug

Document Type: Research Article

Publication date: April 1, 2017

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more