Selective Histone Deacetylase Inhibitors with Anticancer Activity
HDAC inhibitors (HDACIs), which can be used to kill cancer cells through inhibiting histone deacetylase activity or altering the structure of chromatin, have emerged as efficacious agents in the treatment of cancer. With SAHA, FK228, belinostat and panobinostat approved by the FDA,
displaying satisfying activity in both haematological and solid tumors of various tissues, efforts to create selective HDACIs have been attracted attention over the past several years. Herein, we mainly review the progress of selective HDAC inhibitors including class-selective and isoform-selective
HDAC inhibitors.
Keywords: Class I; Class II; Class III; HDAC; HDAC1; HDAC6; Selective histone deacetylase inhibitors
Document Type: Research Article
Publication date: 01 February 2016
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