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Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications

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The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.
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Keywords: Bioreactors; Biosensors; Delivery; Drug; Encapsulation; Sol-gel; Tissue engineering

Document Type: Research Article

Publication date: February 1, 2015

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