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What Does the Future Hold for Photo-Oxidizing RuII Complexes with Polyazaaromatic Ligands in Medicinal Chemistry?

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Since the discovery of cisplatin, the search for diagnostic or therapeutic agents based on other metals, has expanded intensively owing to the numerous possibilities offered by coordination chemistry. This mini-review focuses on recent advances in the search for RuII polyazaaromatic complexes of potential interest as molecular tools applied to cellular diagnostics or as specific cellular photo-reagents for future biomedical applications. The interaction of RuII polyazaaromatic complexes with living cells is reported, as well as the photo-reaction mechanisms of photo-oxidizing RuII complexes with nucleic acids. The novel strategies currently developed to improve their reactivity and specificity towards DNA, more particularly in the gene-silencing framework, are also discussed.

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Keywords: DNA; Diagnostic agent; cell-viability; emission wavelengths; gel electrophoresis analyses; hydrophobic complexes; living cells; luminescent probes; luminophores for biomolecules; nucleic acids; oligonucleotide; photo-oxidizing RuII complexes; photo-therapeutic agent; ruthenium; specific cellular photo-reagents

Document Type: Research Article

Publication date: February 1, 2012

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