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Improvement of Tumor Localization of Photosensitizers for Photodynamic Therapy and Its Application for Tumor Diagnosis
Photodynamic therapy (PDT) and photodynamic diagnosis of cancer are widely used in clinical fields. These are performed using photosensitizers. Many metalloporphyrin-related compounds have been developed as photosensitizers for use in PDT, and these tumor localization ability have been
improved in recent research. Moreover, the precursor of porphyrin 5-aminolevulinic acid is used in fluorescence diagnosis using its tumor localization ability. In this review, these applications of photosensitizers in cancer therapy and diagnosis are summarized.
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Keywords: Photodynamic therapy; aminolevulinic acid; fluorescence diagnosis; hematoporphyrin derivative; hemoglobin; immunoconjugate; ophthalmic tumors; photodynamic diagnosis; photodynamic treatment; photosensitizer; phthalocyanine; porphyrin 5-aminolevulinic acid; target tissues; tumor marker; tumor tissue occurs
Document Type: Research Article
Publication date: February 1, 2012
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