Skip to main content
padlock icon - secure page this page is secure

Multifunctional Ligands in Medicinal Inorganic Chemistry- Current Trends and Future Directions

Buy Article:

$68.00 + tax (Refund Policy)

This review will highlight recent advances in ligand design for innovative applications in medicinal inorganic chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. In an effort to achieve this goal, compounds are being developed that either target a disease site, or are activated by a disease specific biological process. Metal complexes containing targeting functions and/or bioactive ligands, as well as agents that are activated by specific enzymes, or changes in pH and pO2, provide new avenues for drug development. Radiodiagnostic compounds, magnetic resonance imaging agents, and optical probes containing transition metals offer versatility unavailable to organic imaging agents. In certain cases, dual modality agents have been developed, and will be highlighted. Finally, we will discuss targeted metal binding compounds for treatment of metal overload disorders, and the recent application to neurodegenerative disease.

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Medicinal inorganic chemistry; Radiodiagnostic compounds; antiparasitic agents; diagnostic; dual modality imaging; enzymatic transformations; ligand design; metal ion; metal sequestration; multifunctional; multifunctional ligand design; specific biological process; targeted metal binding compounds; therapeutic

Document Type: Research Article

Publication date: February 1, 2012

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more