Platinum Formulations as Anticancer Drugs Clinical and Pre-Clinical Studies
This review summarizes clinical and pre-clinical results on platinum anti-cancer drug formulations. A concise summary of the use of oxidation state to modulate cancer pharmacology is given for Pt(IV) complexes, distinct from the clinically used Pt(II) drugs. The chemistry of platinum
drug formulation combines aspects of kinetics of active moiety release from nominally weak-binding ligands (bond cleavage from platinum-carboxylate and platinum-phosphate) in polymers and nanoparticles with pharmacological considerations of plasma distribution and cellular accumulation. The
action of any molecular entity as a drug is influenced by its ADME profile - absorption, distribution, metabolism and excretion. The purpose of drug formulation is to alter any or all of these parameters with the ultimate goal of improving the efficacy and reducing side effects with the possibility
to target drugs directly to the tumor site. The diverse array of approaches includes liposomes, polymers (not limited to peptides, dendrimers, biodegradable polymers, polysaccharides, and metallic nanoparticles). Functionalization of the surfaces of nanoparticles with antibodies or cellular
surface recognition motifs may further target specific cancers.
Keywords: ADME profile; Chemotherapy; Platinum anti-cancer agents; Platinum-based chemotherapy; absorption, distribution, metabolism and excretion; efficacy; formulation; molecular entity; nanomedicine; nanoparticles; plasma distribution and cellular accumulation; platinum anti-cancer drug formulations; polymer drug delivery; recognition motifs; tumor site
Document Type: Research Article
Publication date: 01 November 2011
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