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Review of 5-HT4R Ligands: State of Art and Clinical Applications

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This article reviews the medicinal implications of 5-HT4R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be antagonists or agonists for 5-HT4R is presented, including chemical structures, binding properties and pharmacological profiles. In the last part of the review, some key concepts concerning structure-activity relationships are highlighted.
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Keywords: 5-HT4 receptor ligands; Agonists; Antagonists; Clinical applications; Serotonin

Document Type: Research Article

Affiliations: Centre d'Etudes et de Recherche sur le Medicament de Normandie (CERMN) UPRES EA 4258,FR CNRS 3038, Universite de Caen, Boulevard Becquerel, 14032 Caen,France.

Publication date: April 1, 2010

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