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Emerging Opportunities and Concerns for Drug Discovery at Serotonin 5-5-HT2B Receptors

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5-HT2B receptors have been reported to play an important role at cardiac, intestinal and central levels, as well as in bone marrow formation and growth. In the last decade, 5-HT2B receptors have also gained much attention as new targets in therapeutics, but also as off-targets because their activation along with the inhibition of serotonin transporters plays a significant role in the pathogenesis of 5-HT induced valvulopathy. Taking this into account, the present review focuses on the new therapeutic applications of 5-HT2B receptor ligands as well as on the potential concerns.
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Document Type: Research Article

Affiliations: Departamento de Farmacologia, Facultad de Farmacia, University of Santiago de Compostela, E-15782 Spain.

Publication date: April 1, 2010

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