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Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands

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This article highlights recent advances in the discovery of new agonists, antagonists and partial agonists of the 5-HT1D receptor. The field of 5-HT1D agonists continues to deliver a number of new potential therapeutic agents, although advances in this field are now more focussed on the clinical evaluation phase. The identification of novel compounds is greater for the 5-HT1D receptor antagonists, and whilst few truly selective ligands have been identified, a number of approaches are discussed towards defined mixed-pharmacology profiles. An overview is also given of recent advances in biological and clinical understanding of the receptor.
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Keywords: 5-HT receptor; 5-HT1D agonist; 5-HT1D antagonist; serotonin receptor

Document Type: Research Article

Affiliations: Neuroscience CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, United Kingdom.

Publication date: April 1, 2010

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