Skip to main content
padlock icon - secure page this page is secure

HM74a Agonists: Will they be the New Generation of Nicotinic Acid?

Buy Article:

$68.00 + tax (Refund Policy)

The discovery of HM74a as a high affinity receptor for nicotinic acid has opened up new areas for investigation. Since its discovery, several new chemical entities have been reported as HM74a agonists. One of them, MK-0354, has been tested in phase II studies, but despite significant decreases in Free Fatty Acid levels with absence of flushing events in clinical studies, it failed to demonstrate effects on LDL-Cholesterol, Triglycerides and HDLCholesterol. These surprising results lead to questions about the reality of HM74a as the unique receptor responsible for the lipid modulating effects of nicotinic acid. This review summarizes these recent developments, and the novel HM74a antagonist structures recently published.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: GPR109a; HDL-Cholesterol; HM74a; Nicotinic Acid; PUMA-G

Document Type: Research Article

Affiliations: Laboratoire GlaxoSmithKline, Centre de Recherches, 25-27 avenue du Quebec, 91951 Les Ulis, France.

Publication date: April 1, 2009

More about this publication?
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more