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Biologically Active Chitosan Systems for Tissue Engineering and Regenerative Medicine

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Biodegradable polymeric scaffolds are widely used as a temporary extracellular matrix in tissue engineering and regenerative medicine. By physical adsorption of biomolecules on scaffold surface, physical entrapment of biomolecules in polymer microspheres or hydrogels, and chemical immobilization of oligopeptides or proteins on biomaterials, biologically active biomaterials and scaffolds can be derived. These bioactive systems show great potential in tissue engineering in rendering bioactivity and/or specificity to scaffolds. This review highlights some of the biologically active chitosan systems for tissue engineering application and the associated strategies to develop such bioactive chitosan systems.
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Keywords: Chitosan; bioactive; biomolecules; regenerative medicine; scaffolds; surface modification; tissue engineering

Document Type: Research Article

Affiliations: Department of Orthopaedic Surgery, University of Virginia, 400 Ray C. Hunt Drive, Suite 330,Charlottesville, VA 22908, USA.

Publication date: March 1, 2008

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