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Inhibitors and Modulators of β- and γ-Secretase

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Most gene mutations associated with Alzheimer's disease point to the metabolism of amyloid precursor protein as potential cause. The β- and γ-secretases are two executioners of amyloid precursor protein processing resulting in amyloid β. Significant progress has been made in the selective inhibition of both proteases, regardless of structural information for γ-secretase. Several peptidic and non-peptidic leads were identified and first drug candidates are in clinical trials. This review focuses on the developments since 2003.
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Keywords: Alzheimer's disease; aspartic protease; inhibitor; presenilin; secretase

Document Type: Research Article

Affiliations: Clemens Schopf-Institute for Organic Chemistry and Biochemistry, TU Darmstadt, Petersenstrasse 22, D- 64287 Darmstadt, Germany.

Publication date: February 1, 2006

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