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Efforts to Understand the Molecular Basis of Hypertension Through Drug:Membrane Interactions

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Biological membranes play an essential role in the drug action. They constitute the first barrier for drugs to exert their biological action. AT1 antagonists are amphiphilic molecules and are hypothesized to act on AT1 receptor through incorporation (first step) and lateral diffusion through membrane bilayers (second step). Various biophysical methods along with Molecular Modelling were applied in order to explore the plausible two step proposed mechanism of action for this class of antihypertensive drugs.
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Keywords: AT1 receptor; Hypertension; antihypertensive drugs

Document Type: Review Article

Affiliations: Institute of Organic and Pharmaceutical Chemistry National Hellenic Research foundation, Vas. Constantinou 48, Athens 11635.

Publication date: February 1, 2004

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