Various Screening Methods for Anti- Asthmatic Activity
Asthma is defined as a complex allergic disease of respiratory system which is characterized by airway inflammation & bronchial hyper-responsiveness to many allergens and due to interaction of many components of immunity system & resident lung cells. Asthma is currently a worldwide problem with around 300 million people around the globe suffering from it and about 250 thousand deaths are reported annually. Asthma remains an area of considerable unmet medical need. Few new drugs have made it to the clinic during the past 50 years, with many that perform well in preclinical animal models of asthma, failing in humans owing to lack of safety and efficacy. The utility of in vivo studies and demand for more predictive models and tools are based on the latest technologies. Studies have been conducted with in vitro and in vivo models but disease mechanism are still unclear. At present, there are no standardized experimental protocol models for asthma, most laboratories have developed and adopted own protocol with little modification. In this article, we discuss various in vivo, in vitro models of asthma which may describe the various mechanisms & pathophysiology involved in allergic and inflammatory disease & also provide investigation of new therapeutic substances for allergic disorders.
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Document Type: Research Article
Publication date: September 1, 2015