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Accelerated Labeling Methods and Syntheses of Radiotracers Utilizing Microfluidic Technology

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Positron emission tomography [PET] is a powerful nuclear clinical imaging technique used for the detection and treatment of central nervous system (CNS) disorders, cardiovascular diseases, and certain cancers. Due to the often short half-lives of the radiolabeled compounds employed, the availability of relevant tracers is severely limited. Through the use of microfluidic techniques many of the limitations of conventional synthesis of radiotracers are alleviated, paving the way for diverse families of compounds to be developed with defined targets for imaging. This review will survey syntheses of various radiotracers using new microfluidic techniques being developed.
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Keywords: Flow chemistry; Microfluidics; PET; green chemistry; labeling; radiopharmaceuticals; synthesis

Document Type: Research Article

Publication date: June 1, 2014

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  • Current Radiopharmaceuticals publishes original research articles, letters, reviews, drug clinical trial studies and guest edited issues on all aspects of research and development of radiolabelled compound preparations. The scope of the journal covers the following areas: radio imaging techniques, therapies; preparation and application of radionuclide compounds including the incorporation of tracer methods used in scientific research and applications.
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