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Polyunsaturated Fatty Acids and their Related Enzymes in Postmortem Brain Tissues of Patients with Psychiatric Disorders

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The first study on fatty acid composition of the postmortem brains of patients with psychiatric disorders was performed by Horrobin et al. in 1991, who found abnormalities in polyunsaturated fatty acids (PUFAs) in patients with schizophrenia. About a decade later, research in this field was re-started by Yao et al., followed by a number of other research groups. The results seem to show that the PUFA changes in psychiatric disorders may be specific to certain brain regions, but the underlying mechanisms remain unclear. Here we review these case-control studies of postmortem brain composition.
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Keywords: bipolar disorder; case-control study; major depressive disorder; polyunsaturated fatty acids; postmortem brain; schizophrenia

Document Type: Research Article

Publication date: February 1, 2013

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  • Current Psychopharmacology publishes peer-reviewed expert review articles and single topic guest edited issues on all aspects of pre-clinical and clinical research in psychopharmacology. The journal aims to be the leading forum for expert review articles in the field. The journal also accepts high-level original research articles on outstanding topics of preclinical and clinical psychopharmacology. Data must be published for the first time in Current Psychopharmacology.
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