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Genomics and Proteomics of Nucleoside Transporters

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Nucleoside transporters are a group of poorly understood membrane proteins involved in the movement of nucleoside and many nucleoside analogs across cell membranes. Nucleoside analog drugs are used routinely in various types of chemotherapy. These drugs have been widely used for many years with good results. However, variability in patient response and both de novo and acquired resistance continue to be major obstacles in effective chemotherapy. In combination with the development of new nucleoside analog drugs, a concerted effort is underway to improve our understanding of the genomics and proteomics of nucleoside transporters in order to identify the factors that influence individual patient responses. Here, we describe recent important contributions to our understanding of the genomics and proteomics of this group of proteins with reference to drug bioavailability. In addition, we discuss future approaches, which will provide further insights into nucleoside transporters structure and function.
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Keywords: ENT genes; Promoter Analyses; amino-terminal motifs; nucleoside transport protein; transcriptional regulators

Document Type: Review Article

Affiliations: Department of Biology, York University, 4700 Keele St., Toronto, M3J 1P3, Canada.

Publication date: December 1, 2005

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  • Current Pharmacogenomics provides comprehensive overviews of all current research on pharmacogenomics and pharmacogenetics. All areas of the field from pre-clinical to clinical research are covered, including related areas such as genomics, proteomics, target discovery, bioinformatics and novel diagnostics. This international journal is peer-reviewed and publishes both mini- and full review articles.

    The journal has become essential reading for all researchers and clinicians with interests in pharmacogenomics and pharmacogenetics.
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