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Genomic Strategies in Transplantation “The Right Drug for the Right Patient”

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Purpose of review: The purpose of this review is to summarize recent advances in the area of genetic polymorphisms in genes affecting immunosuppressive drug bioavailability with a specific emphasis on solid organ transplantation.

Recent findings: Due to recent advances in molecular techniques, there has been an abundance of publications describing genetic variability in molecules relevant to pharmacogenetics. The initial studies in the field of transplantation demonstrate some associations between polymorphisms in these candidate genes with outcomes in organ transplantation.
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Keywords: Transplantation; bioavailability; genetic polymorphisms; immunosuppressive drug

Document Type: Review Article

Affiliations: Mount Sinai School of Medicine, Division of Nephrology, One Gustave L. Levy Place, Box 1243, New York, NY 10029, USA.

Publication date: June 1, 2004

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  • Current Pharmacogenomics provides comprehensive overviews of all current research on pharmacogenomics and pharmacogenetics. All areas of the field from pre-clinical to clinical research are covered, including related areas such as genomics, proteomics, target discovery, bioinformatics and novel diagnostics. This international journal is peer-reviewed and publishes both mini- and full review articles.

    The journal has become essential reading for all researchers and clinicians with interests in pharmacogenomics and pharmacogenetics.
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