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Biology of Protooncogene c-kit Receptor and Spermatogenesis

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Spermatogenesis involves action and interaction of several genes present both on the autosome and sex chromosomes. Protooncogene c-kit receptor is one such autosomal gene implicated with hematopoiesis, melanogenesis and spermatogenesis. A sizable body of literature is available on the regulatory role of this gene, its ligand “stem cell factor” and its functional conservation across the species. Sequences from the extracellular domains of c-kit cDNA show organizational uniqueness across the species conferring species specificity. Studies on fertile and infertile Brown Norway rats enabled identification of mutant mRNA transcript in the testis of infertile animals. These animals showed heavily regressed seminiferous tubules. No such mutant mRNA transcript was detected in the somatic tissues of infertile or normal animals. The mutant mRNA transcript was found in accordance with the regressed seminiferous tubules observed in the testicular histological section of the infertile rats. A perusal of literature and our own study suggest that alternate splicing of c-kit gene gives rise to multiple mRNA transcripts of which at least one is involved in control and regulation of fertility in conjunction with its ligand “stem cell factor” and perhaps other autosomal genes. In this article, we present a brief overview on the organization and expression of protooncogene c-kit receptor and its mutational status in Brown Norway rats (Rattus norvegicus). It is envisaged that information emerging from animal systems will facilitate the overall understanding of the phenomenon of fertility in the human as well.
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Keywords: differential expression; extracellular domain; pleiotropism; rt-pcr; seminomas; spermatogenesis

Document Type: Review Article

Affiliations: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi - 110 067, India

Publication date: March 1, 2004

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  • Current Pharmacogenomics provides comprehensive overviews of all current research on pharmacogenomics and pharmacogenetics. All areas of the field from pre-clinical to clinical research are covered, including related areas such as genomics, proteomics, target discovery, bioinformatics and novel diagnostics. This international journal is peer-reviewed and publishes both mini- and full review articles.

    The journal has become essential reading for all researchers and clinicians with interests in pharmacogenomics and pharmacogenetics.
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