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Targeting IL-23 and Th17-Cytokines in Inflammatory Bowel Diseases

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Over the last 15 years, the use of various biological therapies has largely improved the way we manage patients with Inflammatory Bowel Diseases (IBDs). Blockade of cytokine synthesis and/or activity is at the forefront of this new era with the success of inhibitors of tumor necrosis factor (TNF)-α. These therapies are however not effective in all IBD patients and efficacy may wane. Moreover, patients treated with anti-TNF-α antibodies can develop severe side-effects and new immune-mediated diseases. Therefore, a new challenge is to elucidate new inflammatory networks in the IBD tissue and develop novel anti-cytokine compounds, which may act in patients who are resistant to or cannot receive anti-TNF-α therapies. In this article we review the available data supporting the pathogenic role of IL-23 and Th17-related cytokines in IBD, and discuss whether and how compounds that control the activity of these cytokines may enter into the therapeutic armamentarium of IBD.

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Keywords: ABT-874; Bacteroides fragilis; CD4 cells; Crohn's disease; IBD; IL-12; IL-17A; IL-21; IL-23; Inflammatory Bowel Diseases; Neutralization; SCID mice; T cells; TNBS-colitis; Th17; Th17-Cytokines; anti-TNF- antibodies; anti-cytokine therapy; chemokines; granulocytes; homeostasis; interferon; interleukin; monoclonal antibody; polymorphisms; retinoic acid-related orphan receptor; trinitrobenzenesulfonic acid; tumor necrosis factor; tumours; ulcerative colitis

Document Type: Research Article

Publication date: November 1, 2010

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  • Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

    Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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