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Identification of Novel Drug Targets for Angiostatic Cancer Therapy; It Takes Two to Tango

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The development of novel treatment strategies for therapy of angiogenesis-dependent diseases requires identification of specific tumor endothelial cell markers to which therapeutic agents can be targeted. This can be achieved by random or targeted approaches. Random approaches are based on genomic screening to identify differences between normal and activated endothelium. Targeted approaches utilize known angiogenesis inhibitors to find their molecular targets. Both approaches may lead to the development of angiostatic therapies that are directly targeted towards activated endothelial cells. This review summarizes the recent developments in both approaches.
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Keywords: HUVEC proliferation; NGR binding motifs; Tumor; angiogenesis; endothelial cell based targets

Document Type: Research Article

Affiliations: Department of Pathology,Maastricht University & University Hospital Maastricht, PO Box 5800,6202 AZ Maastricht, The Netherlands.

Publication date: December 1, 2007

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  • Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

    Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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