Skip to main content
padlock icon - secure page this page is secure

Anti-Apoptotic Actions of Insulin-Like Growth Factors: Lessons from Development and Implications in Neoplastic Cell Transformation

Buy Article:

$68.00 + tax (Refund Policy)

Insulin-like growth factor-I (IGF-I) is widely expressed during development, and is actively involved in the regulation of cell growth, proliferation, and differentiation. Underlying these activities is the capacity of IGF-I to promote survival in a variety of cell types, including those of the nervous system. However, in adult tissues deregulation of the IGF system can cause undesired cell survival and therefore excessive cell proliferation. Here, we review the contribution of IGF-I in developmental processes with a focus on the development of the inner ear, as well as pathological implications resulting from IGF-I deregulation during cancer.
No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: Apoptosis; cell transformation; development; neurogenesis; sensory organs; signalling; target genes; transcriptional control

Document Type: Research Article

Publication date: March 1, 2007

More about this publication?
  • Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

    Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more