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Morbidity and Mortality Associated with Pharmacotherapy. Evolution and Current Concept of Drug-Related Problems

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Medicines are a great contribution to the rising life expectancy in XX century. But a lot of drug safety problems were reported since 1960's. More recently, ineffectiveness is also being considered as a problem.

Since 1975, the term 'drug-related problem' (DRP) is being used for several definition and purposes. This has led to a number of different DRP classifications.

The aim of the present review is to gather different positions, definitions and classifications of DRP. And to present a more modern concept, which is also named as pharmacotherapy failure, corresponding to negative clinical outcomes resulting from the use or the lack of use of medicines. Those pharmacotherapy failures include necessity, effectiveness and safety problems.
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Keywords: cerivastatin; grepafloxacin; health problem; ineffectiveness; medicines; primary pulmonary hypertension (pph); reye's syndrome

Document Type: Review Article

Affiliations: Grupo de Investigacion en Atencion Farmaceutica. Facultad de Farmacia. Campus de la Cartuja. 18071 Granada, Spain.

Publication date: December 1, 2004

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  • Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.

    Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.
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